Custom Designer

Create custom Cytos™ workflows for the AVITI24™ System.

ElemBio Cloud Custom Designer™ allows you to create workflows for Cytos chemistry on the AVITI24 System. Cytos is a single-cell multiomics workflow for CRISPR screens and drug discovery on AVITI24, capturing morphology, protein expression, guide RNA, and 3' transcriptome from the same cell in one automated run.

To create a design, follow the setup guide specific to the application. Each setup guide covers the design, the manifest, the planned run, and the metrics reported for that run type:

Design	Modalities	Setup Guide
Cytos Protein	Cell paint + protein	Create a custom design
Cytos Optical Pooled Screening	Cell paint + guide RNA, optional protein	Create a custom design
Cytos 3' Transcriptome	Cell paint + 3' transcriptome, optional protein	Create a custom design
Cytos Multimodal Pooled Screening	Cell paint + guide RNA + 3' transcriptome, optional protein	Create a custom design

Custom designs that are published on ElemBio Cloud are available on connected AVITI24 Systems. Use this page to manage a design after you create it.

Request Access

Don't have an ElemBio Cloud account yet? Request access to Custom Designer.

Import a custom design

You can import an existing custom design into Custom Designer.

1. On the Custom Designer page, select Import a Design.
2. Select the design that you want to import.

Edit a custom design

You can edit a custom design that is in Draft status or add a target cell assignment manifest to a published design.

1. On the Custom Designer page, locate and select the design that you want to edit.
2. Update your custom design as needed.
3. Select Save as Draft, or on the Design Package Preview page, select Publish Design.

   Only published designs can be used in a planned run or manual run on the instrument.

View or download a custom design

To reference a saved custom design, you can view the design or download the design package for a published design.

1. On the Custom Designer page, locate the custom design that you want to view or download a package from.
2. To view the custom design, select the custom design name.
3. (Optional) To download the custom design package, select the three dots (...) in the Actions column, and then select Download Package.

   The custom design package .zip folder is downloaded to your OS.

Clone a custom design

You can clone either a draft or published custom design.

1. On the Custom Designer page, locate the custom design that you want to clone.
2. In the Actions column, select the three dots (...), and then select Clone.
3. Update your cloned custom design as needed.
4. Select Save as Draft, or on the Design Package Preview page, select Publish Design.

   Only published designs can be used in a planned run or manual run on the instrument.

Delete a custom design

You can delete either a draft or published custom design.

1. On the Custom Designer page, locate the custom design that you want to delete.
2. In the Actions column, select the three dots (...), and then select Delete.
3. When the confirmation message appears, select Delete.

See also

• Create a protein screening custom design
• Create an OPS custom design
• Create a 3' Transcriptome custom design
• Create an MPS custom design